Browsing Research Articles by Title
Now showing items 8-24 of 24
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High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda
(Clinical Infectious Diseases, 2017)Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods. We describe the prevalence ... -
HIV-free survival among breastfed infants born to HIV-positive women in northern Uganda: a facility-based retrospective study
(Pan African Medical Journal, 2020)Introduction: the HIV-free survival rate is the gold-standard measure of the effectiveness of interventions towards prevention of mother-to-child transmission of HIV in any setting. However, data on HIV-free survival among ... -
Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
(BMC Medicine, 2018)Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ... -
Lactose intolerance among severely malnourished children with diarrhoea admitted to the nutrition unit, Mulago hospital, Uganda
(BMC Pediatrics, 2010)Background: Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of treatment failure. A combination of nutritional injury and infectious insults in severe protein energy ... -
The management of osteosarcoma in children and adolescents in a resource-limited setting: quality improvement considerations to improve treatment outcomes
(BMC Cancer, 2024)Background The survival rates for children and adolescents with osteosarcoma in low-income countries are poor. Insufficient data regarding the challenges of managing osteosarcoma in resource-limited settings has ... -
Mortality after Fluid Bolus in African Children with Severe Infection
(New England Journal of Medicine, 2011)Background The role of fluid resuscitation in the treatment of children with shock and lifethreatening infections who live in resource-limited settings is not established. Methods We randomly assigned children with ... -
Mortality risk over time after early fluid resuscitation in African children
(Clinical care, 2019)Background: African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk ... -
Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature
(Journal of Medical Case Reports, 2022)Background: There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting. Case presentation: ... -
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
(BMC Medicine, 2015)Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ... -
Prevalence and factors associated with use of herbal medicines during pregnancy among women attending postnatal clinics in Gulu district, Northern Uganda
(BMC Pregnancy and Childbirth, 2016)Background: According to World Health Organization (WHO) estimates, 80 % of the population living in rural areas in developing countries depends on traditional medicine for their health needs, including use during pregnancy. ... -
Prevalence of neonatal sepsis and associated factors among neonates admitted in the neonatal intensive care unit at Lira regional referral hospital, northern Uganda
(Research Square, 2023)BACKGROUND: Sepsis is one of the leading causes of mortality and morbidity among neonates. Neonatal sepsis (NS) contributes to 44% of 5.4 million under-5 mortalities globally, and 12% of neonatal deaths in Uganda in 2020 ... -
Pre‑hospital exposures to antibiotics among children presenting with fever in northern Uganda: a facility‑based cross‑sectional study
(BMC Pediatrics, 2022)Abstract Background: The rise in the indiscriminate use of antibiotics has become a major global public health problem and presents the biggest global health challenge in the twenty-first century. In developing countries, ... -
Reproductive Concerns and Associated Factors Among Adolescent and Young Adult Cancer Survivors in Uganda: A Hospital-Based Cross-Sectional Study
(Journal of Adolescent and Young Adult Oncology., 2024)Purpose: Reproductive health (RH) is a critical issue among cancer survivors worldwide. However, in developing countries where RH services for patients with cancer are often lacking, reproductive concerns among adolescent ... -
Treatment outcome among children underfive years hospitalized with severe acute malnutrition in St. Mary’s hospital Lacor, Northern Uganda
(BMC Nutrition, 2016)Background: Severe malnutrition contributes to more than 60 % of deaths in children in developing countries. The minimum international standard set for management of severe acute malnutrition is a cure rate of at least ... -
Unsatisfactory COVID-19-Related Knowledge, Attitudes and Practices among Undergraduate University Students in Uganda: An Online Cross-Sectional Survey
(Open Journal of Preventive Medicine, 2021)Background: This study examined the COVID-19-related knowledge, attitude and practices among undergraduate students in Uganda. Methods: An online cross-sectional survey was conducted from 12th-19th June 2020 among undergraduate ... -
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
(BMJ Publishing Group Ltd, 2014)Southall made several points about our recent article.1 2 He suggests that “lethal hyperchloraemia” secondary to use of normal saline in FEAST (for boluses or maintenance) resulted in excess mortality. However, he did ... -
WHO guidelines on fluid resuscitation in children: missing the FEAST data
(Bmj, 2014)The World Health Organization recommendations on management of common childhood illnesses affect the lives of millions of children admitted to hospital worldwide. Its latest guidelines,1 released in May 2013, continue ...