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Mortality after Fluid Bolus in African Children with Severe Infection
(New England Journal of Medicine, 2011)
Background
The role of fluid resuscitation in the treatment of children with shock and lifethreatening
infections who live in resource-limited settings is not established.
Methods
We randomly assigned children with ...
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
(BMC Medicine, 2015)
Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission
and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ...
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
(2013)
Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the
48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ...
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
(BMC Medicine, 2015)
Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in
sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group.
Methods: ...
WHO guidelines on fluid resuscitation in children: missing the FEAST data
(Bmj, 2014)
The World Health Organization recommendations on
management of common childhood illnesses affect the lives of
millions of children admitted to hospital worldwide. Its latest
guidelines,1 released in May 2013, continue ...
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
(BMJ Publishing Group Ltd, 2014)
Southall made several points about our recent article.1 2
He suggests that “lethal hyperchloraemia” secondary to use of
normal saline in FEAST (for boluses or maintenance) resulted
in excess mortality. However, he did ...