Browsing Department of Paediatrics and Child Health by Issue Date
Now showing items 1-20 of 24
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Lactose intolerance among severely malnourished children with diarrhoea admitted to the nutrition unit, Mulago hospital, Uganda
(BMC Pediatrics, 2010)Background: Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of treatment failure. A combination of nutritional injury and infectious insults in severe protein energy ... -
Mortality after Fluid Bolus in African Children with Severe Infection
(New England Journal of Medicine, 2011)Background The role of fluid resuscitation in the treatment of children with shock and lifethreatening infections who live in resource-limited settings is not established. Methods We randomly assigned children with ... -
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
(2013)Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the 48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ... -
WHO guidelines on fluid resuscitation in children: missing the FEAST data
(Bmj, 2014)The World Health Organization recommendations on management of common childhood illnesses affect the lives of millions of children admitted to hospital worldwide. Its latest guidelines,1 released in May 2013, continue ... -
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
(BMJ Publishing Group Ltd, 2014)Southall made several points about our recent article.1 2 He suggests that “lethal hyperchloraemia” secondary to use of normal saline in FEAST (for boluses or maintenance) resulted in excess mortality. However, he did ... -
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
(BMC Medicine, 2015)Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ... -
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
(BMC Medicine, 2015)Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group. Methods: ... -
Prevalence and factors associated with use of herbal medicines during pregnancy among women attending postnatal clinics in Gulu district, Northern Uganda
(BMC Pregnancy and Childbirth, 2016)Background: According to World Health Organization (WHO) estimates, 80 % of the population living in rural areas in developing countries depends on traditional medicine for their health needs, including use during pregnancy. ... -
Treatment outcome among children underfive years hospitalized with severe acute malnutrition in St. Mary’s hospital Lacor, Northern Uganda
(BMC Nutrition, 2016)Background: Severe malnutrition contributes to more than 60 % of deaths in children in developing countries. The minimum international standard set for management of severe acute malnutrition is a cure rate of at least ... -
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda
(Clinical Infectious Diseases, 2017)Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods. We describe the prevalence ... -
Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
(BMC Medicine, 2018)Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ... -
Mortality risk over time after early fluid resuscitation in African children
(Clinical care, 2019)Background: African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk ... -
Antibiotic prescription practices among prescribers for children under five at public health centers III and IV in Mbarara district
(PLOS ONE, 2020)Introduction Rational use of medicines requires that patients receive medications appropriate to their clinical needs. Irrational prescription of antibiotics has been reported in many health systems across the world. ... -
HIV-free survival among breastfed infants born to HIV-positive women in northern Uganda: a facility-based retrospective study
(Pan African Medical Journal, 2020)Introduction: the HIV-free survival rate is the gold-standard measure of the effectiveness of interventions towards prevention of mother-to-child transmission of HIV in any setting. However, data on HIV-free survival among ... -
Care Burden and Coping Strategies among Caregivers of Paediatric HIV/AIDS in Northern Uganda: A Cross-Sectional Mixed-Method Study
(Hindawi, 2021)Background. Family caregivers provide the bulk of care to children living with HIV. +is places an enormous demand and care burden on the caregivers who often struggle to cope in various ways, some of which may be maladaptive. ... -
Unsatisfactory COVID-19-Related Knowledge, Attitudes and Practices among Undergraduate University Students in Uganda: An Online Cross-Sectional Survey
(Open Journal of Preventive Medicine, 2021)Background: This study examined the COVID-19-related knowledge, attitude and practices among undergraduate students in Uganda. Methods: An online cross-sectional survey was conducted from 12th-19th June 2020 among undergraduate ... -
Pre‑hospital exposures to antibiotics among children presenting with fever in northern Uganda: a facility‑based cross‑sectional study
(BMC Pediatrics, 2022)Abstract Background: The rise in the indiscriminate use of antibiotics has become a major global public health problem and presents the biggest global health challenge in the twenty-first century. In developing countries, ... -
Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature
(Journal of Medical Case Reports, 2022)Background: There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting. Case presentation: ... -
The clinicopathological profile and value of multidisciplinary management of pediatric brain tumors in a low-income setting
(Taylor & Francis, 2022-10-31)ABSTRACT Brain tumors are the most common solid tumors in children and a leading cause of cancer-related mortality in children worldwide. Data on the epidemiology and management of pediatric brain tumors in Uganda are ... -
Anti-malarial drug use, appropriateness and associated factors among children under-fve with febrile illnesses presenting to a tertiary health facility: a cross sectional study
(Malaria Journal, 2023)Background Malaria is endemic in 95% of Uganda and constitutes the country’s most signifcant public health prob lem—being the leading cause of morbidity and mortality, especially among children under fve years of age. The ...
