Prevalence of HIV-AssociatedMetabolic Abnormalities among Patients Taking First-Line Antiretroviral Therapy in Uganda
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
International Scholarly Research Network
Abstract
Introduction. While the introduction of highly active antiretroviral therapy decreased HIV-related morbidity and mortality rates
in the sub-Saharan Africa, a subsequent increase in metabolic abnormalities has been observed. We sought to determine the
prevalence of HIV-associated metabolic abnormalities among patients on first-line antiretroviral therapy (ART) in an ART clinic
in Kampala, Uganda. Methods. Four hundred forty-two consecutive patients on first-line ART for at least 12 months were screened
for eligibility in a cross-sectional study, and 423 were enrolled. Pre-ART patient characteristics were abstracted from medical
charts, examinations included anthropometric measurement and physical assessment for lipodystrophy. Results. The prevalence
of hyperglycemia and dyslipidemia was 16.3% (69/423) and 81.5% (345/423), respectively. Prevalence of dyslipidemia between
stavudine- and zidovudine-based regimens (91% versus 72%; P < 0.001). Being on stavudine (aOR 4.79, 95%, 2.45–9.38) and
peak body weight (aOR 1.44, 95% CI 1.05–1.97) were independent risk factors for dylipidemia. Stavudine (aOR 0.50, 95% CI
0.27–0.93) use was associated with lower risk for hyperglycemia while, and older age (aOR 1.31, 95% CI 1.11–1.56) and having a
family history of DM (aOR 2.18, 95% CI 1.10–4.34) were independent risk factors for hyperglycemia. Conclusions. HIV-associated
metabolic complications were prevalent among patients on thymidine analogue-containing ART regimens. Screening for lipid and
glucose abnormalities should be considered in ART patients because of cardiovascular risks.
Description
Keywords
Antiretroviral, Metabolic Abnormalities, Uganda
Citation
Omech, B., Sempa, J., Castelnuovo, B., Opio, K., Otim, M., Mayanja-Kizza, H., ... & Manabe, Y. C. (2012). Prevalence of HIV-associated metabolic abnormalities among patients taking first-line antiretroviral therapy in Uganda. International Scholarly Research Notices, 2012.