A case of Shapiro’s Syndrome in an African young man
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Case Reports in Internal Medicine
Abstract
Shapiro’s syndrome is a rare congenital neurological disease characterized by episodes of excessive sweating and
hypothermia, and by complete/partial agenesis of the corpus callosum. We report an 18 year-old male who was referred to
Princess Marina Hopsital with a longstanding history of episodic shaking chills, excessive sweating, fatigue, and unsteady
gait. During the episodes, he was bradycardic (pulse rate of less than 36 beats/minute), with blood pressure of less than
80/45 mmHg, and his axillary body temperatures were unrecordably low. Neurologic examination showed cerebellar
signs. The MRI of the brain revealed agenesis of the corpus callosum with no other abnormalities. The patient responded
to clonidine therapy. Shapiro’s syndrome is an important consideration when evaluating a patient with episodic
hyperhidrosis and hypothermia. The syndrome is rare worldwide and to the best of our knowledge, this report constitutes
the first documentation of a case from Africa.
Description
Keywords
Shapiro’s syndrome, Corpus callosum agenesis, Africa
Citation
Chacha, M. J., Bernard, O., Keatlaretse, S., & Humphrey, B. (2015). A case of Shapiro’s Syndrome in an African young man. Case Rep. Int. Med, 2(2), 72-75.