Browsing Research Articles by Subject "Fluid resuscitation"

Now showing items 1-3 of 3

    • Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial 

      Maitland, Kathryn; George, Elizabeth C; Evans, Jennifer; Kiguli, Sarah; Olupot-Olupot, Peter; Akech, Samuel O; Opoka, Robert O; Engoru, Charles; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Brent, Bernadette; Nteziyaremye, Julius; Mpoya, Ayub; Prevatt, Natalie; Dambisya, Cornelius M; Semakula, Daniel; Ddungu, Ahmed; Okuuny, Vicent; Wokulira, Ronald; Otii, Benedict; Levin, Michael; Crawley, Jane; Babiker, Abdel G; Gibb, Diana M; FEAST trial group (2013)
      Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the 48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ...

    • Mortality risk over time after early fluid resuscitation in African children 

      George, Elizabeth C.; Kiguli, Sarah; Olupot Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel O.; Nyeko, Richard; Mtove, George; Mpoya, Ayub; Thomason, Margaret J.; Crawley, Jane; Evans, Jennifer A.; Gibb, Diana M.; Babiker, Abdel G.; Maitland, Kathryn; Walker, A. Sarah (Clinical care, 2019)
      Background: African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk ...

    • WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall 

      Kiguli, Sarah; Akech, Samuel O; Mtove, George; Opoka, Robert O; Engoru, Charles; Olupot-Olupot, Peter; Nyeko, Richard; Evans, Jennifer; Crawley, Jane; Prevatt, Natalie; Reyburn, Hugh; Levin, Michael; George, Elizabeth C; South, Annabelle; Babiker, Abdel G; Gibb, Diana M; Maitland, Kathryn (BMJ Publishing Group Ltd, 2014)
      Southall made several points about our recent article.1 2 He suggests that “lethal hyperchloraemia” secondary to use of normal saline in FEAST (for boluses or maintenance) resulted in excess mortality. However, he did ...