Browsing Research Articles by Author "Nyeko, Richard"
Now showing items 1-19 of 19
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Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
Kiguli, Sarah; Maitland, Kathryn; George, Elizabeth C; Olupot-Olupot, Peter; Opoka, Robert O; Engoru, Charles; Akech, Samuel O; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Levin, Michael; Babiker, Abdel G; Gibb, Diana M; Crawley, Jane (BMC Medicine, 2015)Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group. Methods: ... -
Anti-malarial drug use, appropriateness and associated factors among children under-fve with febrile illnesses presenting to a tertiary health facility: a cross sectional study
Nyeko, Richard; Otim, Felix; Obiya, Evelyn Miriam; Abala, Catherine (Malaria Journal, 2023)Background Malaria is endemic in 95% of Uganda and constitutes the country’s most signifcant public health prob lem—being the leading cause of morbidity and mortality, especially among children under fve years of age. The ... -
The clinicopathological profile and value of multidisciplinary management of pediatric brain tumors in a low-income setting
Nyeko, Richard; Kambugu, Joyce Balagadde; Angom, Racheal; Senyonjo, Hussein; Kibudde, Solomon; Geriga, Fadhil; van Heerden, Jaques (Taylor & Francis, 2022-10-31)ABSTRACT Brain tumors are the most common solid tumors in children and a leading cause of cancer-related mortality in children worldwide. Data on the epidemiology and management of pediatric brain tumors in Uganda are ... -
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
Maitland, Kathryn; George, Elizabeth C; Evans, Jennifer; Kiguli, Sarah; Olupot-Olupot, Peter; Akech, Samuel O; Opoka, Robert O; Engoru, Charles; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Brent, Bernadette; Nteziyaremye, Julius; Mpoya, Ayub; Prevatt, Natalie; Dambisya, Cornelius M; Semakula, Daniel; Ddungu, Ahmed; Okuuny, Vicent; Wokulira, Ronald; Otii, Benedict; Levin, Michael; Crawley, Jane; Babiker, Abdel G; Gibb, Diana M; FEAST trial group (2013)Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the 48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ... -
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda
Olupot-Olupot, Peter; Engoru, Charles; Uyoga, Sophie; Muhindo, Rita; Macharia, Alex; Kiguli, Sarah; Opoka, Robert O; Akech, Samuel; Ndila, Carolyne; Nyeko, Richard; Mtove, George; Nteziyaremye, Julius; Chebet, Martin; George, Elizabeth C; Babiker, Abdel G; Gibb, Diana M; Williams, Thomas N.; Maitland, Kathryn (Clinical Infectious Diseases, 2017)Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods. We describe the prevalence ... -
HIV-free survival among breastfed infants born to HIV-positive women in northern Uganda: a facility-based retrospective study
Aguti, Irene; Kimbugwe, Charles; Apai, Patricia; Munyaga, Siraji; Nyeko, Richard (Pan African Medical Journal, 2020)Introduction: the HIV-free survival rate is the gold-standard measure of the effectiveness of interventions towards prevention of mother-to-child transmission of HIV in any setting. However, data on HIV-free survival among ... -
Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
Aramburo, A; Todd, Jim; George, Elizabeth C.; Kiguli, Sarah; Olupot-Olupot, Peter; Opoka, Robert O; Engoru, Charles; Akech, Samuel O; Nyeko, Richard; Mtove, George; Gibb, Diana M; Babiker, Abdel G; Maitland, Kathryn (BMC Medicine, 2018)Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ... -
Lactose intolerance among severely malnourished children with diarrhoea admitted to the nutrition unit, Mulago hospital, Uganda
Nyeko, Richard; Kalyesubula, Israel; Mworozi, Edison; Bachou, Hanifa (BMC Pediatrics, 2010)Background: Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of treatment failure. A combination of nutritional injury and infectious insults in severe protein energy ... -
Mortality after Fluid Bolus in African Children with Severe Infection
Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O.; Engoru, Charles; Olupot-Olupot, Peter; Akech, Samuel O.; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Lang, Trudie; Brent, Bernadette; Evans, Jennifer A.; Tibenderana, James K.; Crawley, Jane; Russell, Elizabeth C.; Levin, Michael; Babiker, Abdel G.; Gibb, Diana M. (New England Journal of Medicine, 2011)Background The role of fluid resuscitation in the treatment of children with shock and lifethreatening infections who live in resource-limited settings is not established. Methods We randomly assigned children with ... -
Mortality risk over time after early fluid resuscitation in African children
George, Elizabeth C.; Kiguli, Sarah; Olupot Olupot, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel O.; Nyeko, Richard; Mtove, George; Mpoya, Ayub; Thomason, Margaret J.; Crawley, Jane; Evans, Jennifer A.; Gibb, Diana M.; Babiker, Abdel G.; Maitland, Kathryn; Walker, A. Sarah (Clinical care, 2019)Background: African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk ... -
Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature
Nyeko, Richard; Geriga, Fadhil; Angom, Racheal; Kambugu, Joyce Balagadde (Journal of Medical Case Reports, 2022)Background: There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting. Case presentation: ... -
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
George, Elizabeth C.; Walker, A. Sarah; Kiguli, Sarah; Olupot-Olupo, Peter; Opoka, Robert O.; Engoru, Charles; Akech, Samuel O.; Nyeko, Richard; Mtove, George; Reyburn, Hugh; Berkley, James A.; Mpoya, Ayub; Levin, Michael; Crawley, Jane; Gibb, Diana M.; Maitland, Kathryn; Babiker, Abdel G. (BMC Medicine, 2015)Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ... -
Prevalence and factors associated with use of herbal medicines during pregnancy among women attending postnatal clinics in Gulu district, Northern Uganda
Nyeko, Richard; Tumwesigye, Nazarius Mbona; Halage, Abdullah Ali (BMC Pregnancy and Childbirth, 2016)Background: According to World Health Organization (WHO) estimates, 80 % of the population living in rural areas in developing countries depends on traditional medicine for their health needs, including use during pregnancy. ... -
Pre‑hospital exposures to antibiotics among children presenting with fever in northern Uganda: a facility‑based cross‑sectional study
Nyeko, Richard; Otim, Felix; Obiya, Evelyn Miriam; Abala, Catherine (BMC Pediatrics, 2022)Abstract Background: The rise in the indiscriminate use of antibiotics has become a major global public health problem and presents the biggest global health challenge in the twenty-first century. In developing countries, ... -
Reproductive Concerns and Associated Factors Among Adolescent and Young Adult Cancer Survivors in Uganda: A Hospital-Based Cross-Sectional Study
Nyeko, Richard; Okello, Nelson; Abeja, Christine Joy; Adyanga, Proscovia; Apio, Betty; Nabasirye, Caroline Kambugu; Mwa, Pamella Aol; Angom, Racheal; Geriga, Fadhil; Buser, Julie (Journal of Adolescent and Young Adult Oncology., 2024)Purpose: Reproductive health (RH) is a critical issue among cancer survivors worldwide. However, in developing countries where RH services for patients with cancer are often lacking, reproductive concerns among adolescent ... -
Treatment outcome among children underfive years hospitalized with severe acute malnutrition in St. Mary’s hospital Lacor, Northern Uganda
Nyeko, Richard; Calbi, Valeria; Ssegujja, Boniface Otto; Ayot, Grace Flona (BMC Nutrition, 2016)Background: Severe malnutrition contributes to more than 60 % of deaths in children in developing countries. The minimum international standard set for management of severe acute malnutrition is a cure rate of at least ... -
Unsatisfactory COVID-19-Related Knowledge, Attitudes and Practices among Undergraduate University Students in Uganda: An Online Cross-Sectional Survey
Nyeko, Richard; Amanya, Sharon B.; Aleni, Mary; Akello, Franceska (Open Journal of Preventive Medicine, 2021)Background: This study examined the COVID-19-related knowledge, attitude and practices among undergraduate students in Uganda. Methods: An online cross-sectional survey was conducted from 12th-19th June 2020 among undergraduate ... -
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
Kiguli, Sarah; Akech, Samuel O; Mtove, George; Opoka, Robert O; Engoru, Charles; Olupot-Olupot, Peter; Nyeko, Richard; Evans, Jennifer; Crawley, Jane; Prevatt, Natalie; Reyburn, Hugh; Levin, Michael; George, Elizabeth C; South, Annabelle; Babiker, Abdel G; Gibb, Diana M; Maitland, Kathryn (BMJ Publishing Group Ltd, 2014)Southall made several points about our recent article.1 2 He suggests that “lethal hyperchloraemia” secondary to use of normal saline in FEAST (for boluses or maintenance) resulted in excess mortality. However, he did ... -
WHO guidelines on fluid resuscitation in children: missing the FEAST data
Kiguli, Sarah; Akech, Samuel O; Mtove, George; Opoka, Robert O; Engoru, Charles; Olupot-Olupot, Peter; Nyeko, Richard; Evans, Jennifer; Crawley, Jane; Prevatt, Natalie; Reyburn, Hugh; Levin, Michael; George, Elizabeth C; Babiker, Abdel G; Gibb, Diana M; Maitland, Kathryn (Bmj, 2014)The World Health Organization recommendations on management of common childhood illnesses affect the lives of millions of children admitted to hospital worldwide. Its latest guidelines,1 released in May 2013, continue ...