Browsing Department of Pharmacology by Author "Gustafsson, Lars L"
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Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination
Ntale, Muhammad.; Obua, celestino; Mukonzo, Jackson; Mahindi, Margarita; Gustafsson, Lars L; Beck, Olof; Ogwal-Okeng, Jasper (Malaria Journal, 2009)Background: Artemisinin combination therapy (ACT) has been widely adopted as first-line treatment for uncomplicated falciparum malaria. In Uganda, amodiaquine plus artesunate (AQ+AS), is the alternative first-line regimen ... -
Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a prospective cohort study
Mukonzo, Jackson K; Okwera, Alphonse; Nakasujja, Neoline; Luzze, Henry; Waako, Paul.; Ogwal-Okeng, Jasper; Gustafsson, Lars L; Aklillu, Eleni (BMC Infectious Diseases, 2013)Background: HIV infection, anti-tuberculosis and efavirenz therapy are associated with neuropsychological effects. We evaluated the influence of rifampicin cotreatment, efavirenz pharmacokinetics and pharmacogenetics ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.
Mukonzo, Jackson K.; Röshammar, Daniel; Waako, Paul J; Andersson, Maria; Fukasawa, Takashi; Milani, Lili; Svensson, Jan Olof; Ogwal-Okeng, Jasper; Gustafsson, Lars L; Aklillu, Eleni (British Journal of Clinical Pharmacology, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ...