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Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
(BMC Medicine, 2018)
Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis
and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ...
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
(BMC Medicine, 2015)
Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission
and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ...
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
(2013)
Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the
48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ...
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
(BMC Medicine, 2015)
Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in
sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group.
Methods: ...
Pre‑hospital exposures to antibiotics among children presenting with fever in northern Uganda: a facility‑based cross‑sectional study
(BMC Pediatrics, 2022)
Abstract
Background: The rise in the indiscriminate use of antibiotics has become a major global public health problem and
presents the biggest global health challenge in the twenty-first century. In developing countries, ...
Treatment outcome among children underfive years hospitalized with severe acute malnutrition in St. Mary’s hospital Lacor, Northern Uganda
(BMC Nutrition, 2016)
Background: Severe malnutrition contributes to more than 60 % of deaths in children in developing countries. The
minimum international standard set for management of severe acute malnutrition is a cure rate of at least ...
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
(BMJ Publishing Group Ltd, 2014)
Southall made several points about our recent article.1 2
He suggests that “lethal hyperchloraemia” secondary to use of
normal saline in FEAST (for boluses or maintenance) resulted
in excess mortality. However, he did ...
Anti-malarial drug use, appropriateness and associated factors among children under-fve with febrile illnesses presenting to a tertiary health facility: a cross sectional study
(Malaria Journal, 2023)
Background Malaria is endemic in 95% of Uganda and constitutes the country’s most signifcant public health prob lem—being the leading cause of morbidity and mortality, especially among children under fve years of age. The ...