Browsing Faculty of Medicine by Title
Now showing items 121-140 of 191
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Neuroinflammation and Not Tauopathy Is a Predominant Pathological Signature of Nodding Syndrome
(Journal of Neuropathology & Experimental Neurology, 2019)Nodding syndrome (NS) is an epileptic disorder occurring in chil dren in African onchocerciasis endemic regions. Here, we describe the pathological changes in 9 individuals from northern Uganda who died with NS (n ¼ 5) ... -
Neuropathological Changes in Nakalanga Syndrome—A Case Report
(Pathogens, 2021)Nakalanga syndrome is a clinical manifestation of onchocerciasis-associated epilepsy characterized by stunting, delayed or absent secondary sexual development and skeletal deformities, and is often accompanied by epileptic ... -
Nodding syndrome in Uganda is a tauopathy
(Acta neuropathologica, 2018)Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13–18 years of ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.
(British Journal of Clinical Pharmacology, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ... -
Obstetric Referrals to a Tertiary Hospital in Northern Uganda - A One Year Experience
(Jemds.com, 2020)BACKGROUND Delay in referral adversely affects maternal and neonatal outcome. We wanted to review the obstetric referrals, source of referrals, appropriateness of referrals and document the maternal and perinatal outcomes ... -
Off-label antibiotic use among paediatric in-patients: a mixed-method prospective study at a tertiary hospital in southwestern Uganda
(International Journal of Clinical Pharmacy, 2020)Background The off-label use of drugs to treat children is a global practice attributed to the traditional exclusion of children from clinical trials mainly due to practical and ethical reasons. Off-label drug use carries ... -
Oral–visceral iatrogenic Kaposi sarcoma following treatment for acute lymphoblastic leukemia: a case report and review of the literature
(Journal of Medical Case Reports, 2022)Background: There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting. Case presentation: ... -
Patterns and Predictors of Self-Medication in Northern Uganda
(PLOS ONE, 2014)Self-medication with antimicrobial agents is a common form of self-care among patients globally with the prevalence and nature differing from country to country. Here we assessed the prevalence and predictors of antimicrobial ... -
Personality and Mental Health among Lira University Students during the COVID-19 Pandemic
(International Journal of Academic Research in Psychology, 2020)Abstract COVID-19 pandemic is one of the 21st -century major health crises affecting the world. Due to the pandemic, education activities were disrupted and examinations were postponed. This could have far-reaching effects ... -
Phenomenology of Induced Abortion in Northern Uganda Among HIV-Positive Women Following an Unintended Pregnancy
(Open Access Journal of Contraception, 2023)Background: More than half of pregnancies in Uganda are unintended, and nearly a third of these end in abortion. However, little research has focused on women living with HIV’s subjective experiences following induced ... -
Phytochemical Analysis and Screening of Ugandan Medicinal Plants for Antifungal Activity against Candida albicans
(International Journal of Tropical Disease & Health, 2015)Aims: The potential activity against Candida albicans of five commonly used medicinal plant species of Bwindi Impenetrable Forest National Park in southwestern Uganda was investigated. Study Design: The phytochemical ... -
Phytochemicals and acute toxicity of Moringa oleifera roots in mice
(Journal of Pharmacognosy and Phytotherapy, 2011)The phytochemicals used by plants to protect themselves against predators in Moringa oleifera roots were qualitatively identified in the aqueous and ethanol extracts. Its acute toxicity in 24 h was evaluated in Swiss albino ... -
Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities
(Journal of Medicinal Plants Research, 2010)Moringa oleifera grown and used in many countries around the world is a multi-purpose tree with medicinal, nutritional and socio-economic values. In Senegal and Benin, M. oleifera leaves are dispensed as powder at health ... -
Plasma levels of DDE/DDT and liver function in malaria control personnel 6 months after indoor residual spraying with DDT in northern Uganda, 2008
(South African Medical Journal, 2008)Objective. We investigated the relationship between plasma levels of dichlorodiphenyltrichloroethane (DDT) and liver function in malaria control personnel 6 months after one round of DDT indoor residual spraying ... -
Post-Traumatic Stress Disorder and Coping Strategies Among People with HIV in Lira District, Uganda: A Cross-Sectional Study
(Dovepress, 2022)Background: Post-traumatic stress disorder (PTSD) is the most commonly reported mental health consequence following traumatic events. However, little is known about how people with HIV cope with the PTSD burden in Lira ... -
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
(BMC Medicine, 2015)Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ... -
Predictors of Adherence to Routine Immunization Schedule Among Caretakers of Children Aged 10 to 18 Months in Lira City, Uganda
(Global Pediatric Health, 2022)Background. Although the majority of nations have routine immunization programs in place as a public health strategy, more than 1.5 million children under the age of 5 die yearly worldwide due to inadequate vaccination ... -
Predictors of Unintended Pregnancy Among Adolescent Girls During the Second Wave of COVID-19 Pandemic in Oyam District in Northern Uganda
(Open Access Journal of Contraception, 2023)Background: In Uganda, unintended pregnancies are responsible for one in three births with detrimental consequences, a situation that worsened during COVID-19. Thus, the present examined unplanned pregnancy and its ... -
Prevalence and Antimicrobial Susceptibility Pattern of Extended Spectrum Beta Lactamase Producers in Gram-negative Urine Isolates at MBN Clinical Laboratories, Kampala Uganda
(Archives of Microbiology & Immunology, 2018)Introduction: Occurrence of Extended Spectrum beta-lactamase (ESBLs) producing bacteria have presented impediment in treatment choices for urinary tract infections. ESBLs embody a major cluster of lactamases accountable ... -
Prevalence and contextual factors associated with compassion fatigue among nurses in northern Uganda
(PLOS ONE, 2021)Background Compassion fatigue is associated with negative consequences that undermine workplace performance. However, literature is scarce on compassion fatigue among nurses in the context of Uganda who are at higher ...