| dc.contributor.author | Ogwal-Okeng, Jasper | |
| dc.contributor.author | Obua, Celestino. | |
| dc.contributor.author | Anokbonggo, William W. | |
| dc.date.accessioned | 2020-10-02T17:48:16Z | |
| dc.date.available | 2020-10-02T17:48:16Z | |
| dc.date.issued | 2003 | |
| dc.identifier.citation | Ogwal-Okeng, J. W., Obua, C., & Anokbonggo, W. W. (2003). Acute toxicity effects of the methanolic extract of Fagara zanthoxyloides (Lam.) root-bark. African Health Sciences, 3(3), 124-126. | en_US |
| dc.identifier.uri | https://hdl.handle.net/123456789/168 | |
| dc.description.abstract | Background: Fagara zanthoxyloides is a well known medicinal plant in Uganda. It is used extensively in malaria and other
infections. However nothing is known about its toxicity.
Objective: The objective of the study was to evaluate the acute toxicity of the methanolic extract of the root-bark of F.
zanthoxyloides, in mice.
Methods: Methanolic extract of the root-bark of the plant was administered orally to mice at various dose levels to determine
the acute toxic effects and the median lethal dose (LD50) in mice.
Results: The LD50 of the methanolic extract was found to be 5.0 g/Kg body weight within 95 % confidence limits. The mice
showed signs of cerebral irritation before dying. Histopathological examinations of the viscera showed congestion and focal
necrosis of the liver and renal tubules.
Conclusion: It was concluded that the extract of F. zanthoxyloides is safe, however the cerebral mechanism that lead to the death
of the mice need to be investigated further. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | African Health Sciences | en_US |
| dc.subject | Fagara zanthoxyloides | en_US |
| dc.subject | medicinal plants | en_US |
| dc.subject | toxicity | en_US |
| dc.subject | Uganda | en_US |
| dc.title | Acute toxicity effects of the methanolic extract of Fagara zanthoxyloides (Lam.) root-bark | en_US |
| dc.type | Article | en_US |
