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Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the 48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ...
Mortality risk over time after early fluid resuscitation in African children
(Clinical care, 2019)
Background: African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk ...
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
(BMJ Publishing Group Ltd, 2014)
Southall made several points about our recent article.1 2 He suggests that “lethal hyperchloraemia” secondary to use of normal saline in FEAST (for boluses or maintenance) resulted in excess mortality. However, he did ...