Now showing items 1-6 of 6
Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
(BMC Medicine, 2018)
Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ...
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the 48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ...
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
(BMC Medicine, 2015)
Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group. Methods: ...
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda
(Clinical Infectious Diseases, 2017)
Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods. We describe the prevalence ...
WHO guidelines on fluid resuscitation in children: missing the FEAST data
The World Health Organization recommendations on management of common childhood illnesses affect the lives of millions of children admitted to hospital worldwide. Its latest guidelines,1 released in May 2013, continue ...
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
(BMJ Publishing Group Ltd, 2014)
Southall made several points about our recent article.1 2 He suggests that “lethal hyperchloraemia” secondary to use of normal saline in FEAST (for boluses or maintenance) resulted in excess mortality. However, he did ...