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A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.
(British Journal of Clinical Pharmacology, 2009)
AIMS
Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim
was to develop an integrated population pharmacokinetic/pharmacogenetic model and
investigate the impact of genetic variations, ...
Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination
(Malaria Journal, 2009)
Background: Artemisinin combination therapy (ACT) has been widely adopted as first-line
treatment for uncomplicated falciparum malaria. In Uganda, amodiaquine plus artesunate (AQ+AS),
is the alternative first-line regimen ...
Existing capacity to manage pharmaceuticals and related commodities in East Africa
(BioMed Central : Human Resources for Health, 2009)
Background: East African countries have in the recent past experienced a tremendous increase in the volume of
antiretroviral drugs. Capacity to manage these medicines in the region remains limited. Makerere University, ...