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Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
(BMC Medicine, 2018)
Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis
and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ...
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
(2013)
Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the
48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ...
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
(BMC Medicine, 2015)
Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in
sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group.
Methods: ...
WHO guidelines on fluid resuscitation in children : Authors’ reply to Southall
(BMJ Publishing Group Ltd, 2014)
Southall made several points about our recent article.1 2
He suggests that “lethal hyperchloraemia” secondary to use of
normal saline in FEAST (for boluses or maintenance) resulted
in excess mortality. However, he did ...