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Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa
(BMC Medicine, 2018)
Background: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis
and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of ...
Mortality after Fluid Bolus in African Children with Severe Infection
(New England Journal of Medicine, 2011)
Background
The role of fluid resuscitation in the treatment of children with shock and lifethreatening
infections who live in resource-limited settings is not established.
Methods
We randomly assigned children with ...
Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score
(BMC Medicine, 2015)
Background: Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission
and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify ...
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
(2013)
Background: Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the
48-hour mortality by 3.3% compared with controls (no bolus). We explored the effect of boluses on 48-hour ...
Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
(BMC Medicine, 2015)
Background: Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in
sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group.
Methods: ...
Prevalence and factors associated with use of herbal medicines during pregnancy among women attending postnatal clinics in Gulu district, Northern Uganda
(BMC Pregnancy and Childbirth, 2016)
Background: According to World Health Organization (WHO) estimates, 80 % of the population living in rural
areas in developing countries depends on traditional medicine for their health needs, including use during
pregnancy. ...
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda
(Clinical Infectious Diseases, 2017)
Background. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants
from eastern Uganda presented with blackwater fever (BWF).
Methods. We describe the prevalence ...
Mortality risk over time after early fluid resuscitation in African children
(Clinical care, 2019)
Background: African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid
Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk ...
Lactose intolerance among severely malnourished children with diarrhoea admitted to the nutrition unit, Mulago hospital, Uganda
(BMC Pediatrics, 2010)
Background: Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of
treatment failure. A combination of nutritional injury and infectious insults in severe protein energy ...
Treatment outcome among children underfive years hospitalized with severe acute malnutrition in St. Mary’s hospital Lacor, Northern Uganda
(BMC Nutrition, 2016)
Background: Severe malnutrition contributes to more than 60 % of deaths in children in developing countries. The
minimum international standard set for management of severe acute malnutrition is a cure rate of at least ...